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TEHRAN, Iran — A commercial plane crashed on Sunday in a foggy, mountainous region of Iran, most likely killing all 66 people on board, the state news media reported.

The Iran Aseman Airlines plane went down near its destination, the city of Yasuj, about 485 miles south of the capital, Tehran.

Mohammad Taghi Tabatabai, a spokesman for Aseman Airlines, initially told state television that everyone aboard the ATR-72, a twin-engine turboprop used for short-distance regional flights, had been killed.

The airline later issued a statement saying it could not reach the crash site and could not “accurately and definitely confirm” everyone had died.

The plane was carrying 60 passengers, including one child, and six crew members, according to The Associated Press. The cause of the crash was not immediately clear.

The Iranian Red Crescent said it had sent people to the area, and the authorities said they would be investigating.

But fog prevented rescue helicopters from reaching the site in the Zagros Mountains, state TV reported. Mr. Tabatabai said the plane had crashed into Mount Dena, which has an elevation of about 14,500 feet.

News reports said the plane disappeared from radar screens 50 minutes after taking off from Mehrabad International Airport, in western Tehran, which mainly serves domestic flights but has some international routes.

Under decades of international sanctions, Iran’s commercial passenger aircraft fleet has aged, with accidents occurring regularly in recent years.

The sanctions have prevented the oil-rich country from updating its fleet, forcing it to use substandard Russian planes and to patch up older jets far past their normal years of service, drawing on spare parts bought on the black market.

In 2014, a locally built Iranian passenger plane crashed shortly after takeoff from Mehrabad Airport, killing 39 people and reviving questions about the safety of an aviation sector hobbled by sanctions.

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That plane was based on a relatively obscure Ukrainian design that had been involved in previous Iranian air disasters. The Sepahan Air regional airliner, bound for Tabas in eastern Iran, went down in a residential area shortly after takeoff at 9:20 a.m.

In November 2006, an Iranian military plane crashed at Mehrabad Airport, killing all 38 people on board, including 35 members of the Islamic Revolutionary Guards Corps, state television reported.

The Antonov 74 aircraft, headed to Shiraz in the south of Iran, crashed shortly after takeoff, the airport’s director said.

Earlier that year, a plane carrying 147 passengers caught fire while landing in northeastern Iran, killing 29 people and injuring 47.

The plane, a Russian-made Tupolev-154, apparently blew a tire while landing in Mashhad, slipped off the runway and burst into flames, the governor of Khorasan Province said.

After the landmark nuclear deal with world powers in 2015, Iran signed deals with Airbus and Boeing to buy scores of passenger planes.

The ATR 72 involved in the crash on Sunday, a French-Italian short-haul aircraft, was introduced in the late 1980s. The fleet of Aseman Airlines was delivered from 1993 to 2009.

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